2016 Publications

Davoli, T., Mengwasser, K. E., Duan, J., Chen, T., Christensen, C., Wooten, E. C., … Elledge, S. J. (2016). Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development, 30(24), 2684–2695. http://doi.org/10.1101/gad.290122.116
Duran, D., Jin, S. C., DeSpenza, T., Nelson-Williams, C., Cogal, A. G., Abrash, E. W., … Kahle, K. T. (2016). Digenic mutations of human OCRL paralogs in Dent’s disease type 2 associated with Chiari I malformation. Human Genome Variation, 3(1), 16042. http://doi.org/10.1038/hgv.2016.42
Kahle, K. T., Kulkarni, A. V, Limbrick, D. D., & Warf, B. C. (2016). Hydrocephalus in children. The Lancet, 387(10020), 788–799. http://doi.org/10.1016/S0140-6736(15)60694-8
Zhang, J., Deng, X., & Kahle, K. T. (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450), pe3-pe3. http://doi.org/10.1126/scisignal.aaj2227
Kahle, K. T., Khanna, A. R., Duan, J., Staley, K. J., Delpire, E., & Poduri, A. (2016). The KCC2 Cotransporter and Human Epilepsy. The Neuroscientist, 22(6), 555–562. http://doi.org/10.1177/1073858416645087
Karimy, J. K., Duran, D., Hu, J. K., Gavankar, C., Gaillard, J. R., Bayri, Y., … Kahle, K. T. (2016). Cerebrospinal fluid hypersecretion in pediatric hydrocephalus. Neurosurgical Focus, 41(5), E10. http://doi.org/10.3171/2016.8.FOCUS16278
Zhang, J., Gao, G., Begum, G., Wang, J., Khanna, A. R., Shmukler, B. E., … Kahle, K. T. (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1), 35986. http://doi.org/10.1038/srep35986
Lucchesi, K. M., Grant, R., Kahle, K. T., Marks, A. M., & DiLuna, M. L. (2016). Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database. Journal of Neuro-Oncology, 130(1), 133–140. http://doi.org/10.1007/s11060-016-2218-6
Kahle, K. T., Flores, B., Bharucha-Goebel, D., Zhang, J., Donkervoort, S., Hegde, M., … Delpire, E. (2016). Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling, 9(439), ra77-ra77. http://doi.org/10.1126/scisignal.aae0546
Kahle, K. T., Schmouth, J.-F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., … Rouleau, G. A. (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling, 9(421), ra32-ra32. http://doi.org/10.1126/scisignal.aad0163
Merner, N. D., Mercado, A., Khanna, A. R., Hodgkinson, A., Bruat, V., Awadalla, P., … Kahle, K. T. (2016). Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia. Journal of Psychiatric Research, 77, 22–26. http://doi.org/10.1016/j.jpsychires.2016.02.016
Terry, A. R., Kahle, K. T., Larvie, M., Vyas, J. M., & Stemmer-Rachamimov, A. (2016). Case 5-2016. New England Journal of Medicine, 374(7), 671–680. http://doi.org/10.1056/NEJMcpc1509361
Leasure, A., Kimberly, W. T., Sansing, L. H., Kahle, K. T., Kronenberg, G., Kunte, H., … Sheth, K. N. (2016). Treatment of Edema Associated With Intracerebral Hemorrhage. Current Treatment Options in Neurology, 18(2), 9. http://doi.org/10.1007/s11940-015-0392-z
Kahle, K. T., & Delpire, E. (2016). Kinase-KCC2 coupling: Cl − rheostasis, disease susceptibility, therapeutic target. Journal of Neurophysiology, 115(1), 8–18. http://doi.org/10.1152/jn.00865.2015