February 18, 2016
Volume 374, Issue 7
Case Records of MGH. Case 5-2016. A 43-Year-Old Man with Altered Mental Status and a History of Alcohol Use
A 43-year-old man with a history of alcohol-use disorder was admitted to this hospital because of altered mental status.
On the day of admission, the patient was found by emergency medical services personnel, who had been contacted by a neighbor. He was sitting on a mattress, was incontinent of feces and urine, and was surrounded by empty prescription containers for gabapentin and bupropion...
February 20, 2016
Volume 387, Issue 10020
Hydrocephalus in children
Hydrocephalus is a common disorder of cerebral spinal fluid (CSF) physiology resulting in abnormal expansion of the cerebral ventricles. Infants commonly present with progressive macrocephaly whereas children older than 2 years generally present with signs and symptoms of intracranial hypertension. The classic understanding of hydrocephalus as the result of obstruction to bulk flow of CSF is evolving to models that incorporate dysfunctional cerebral pulsations, brain compliance, and newly...
December 15, 2016
Volume 30, Issue 24
Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover
Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are frequently identified in cancer. To identify pathways that support PI3K oncogenesis, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type or mutant PIK3CA to search for PI3K synthetic-lethal (SL) genes...