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Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015). GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia, 63(1), 23–36.
Kahle, K. T., Khanna, A. R., Alper, S. L., Adragna, N. C., Lauf, P. K., Sun, D., & Delpire, E. (2015). K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in Molecular Medicine, 21(8), 513–523.
Begum, G., Yuan, H., Kahle, K. T., Li, L., Wang, S., Shi, Y., … Sun, D. (2015). Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke, 46(7), 1956–1965.
Friedel, P., Kahle, K. T., Zhang, J., Hertz, N., Pisella, L. I., Buhler, E., … Medina, I. (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383), ra65-ra65.
Khanna, A., Simard, J. M., & Kahle, K. T. (2015). Progesterone in Traumatic Brain Injury. New England Journal of Medicine, 372(18), 1765–1767.
Karimy, J. K., Kahle, K. T., Kurland, D. B., Yu, E., Gerzanich, V., & Simard, J. M. (2015). A novel method to study cerebrospinal fluid dynamics in rats. Journal of Neuroscience Methods, 241, 78–84.
Adragna, N. C., Ravilla, N. B., Lauf, P. K., Begum, G., Khanna, A. R., Sun, D., & Kahle, K. T. (2015). Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Frontiers in Cellular Neuroscience, 9, 255.
Merner, N. D., Chandler, M. R., Bourassa, C., Liang, B., Khanna, A. R., Dion, P., … Kahle, K. T. (2015). Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience, 9, 386.
Ang, J. W. J., Khanna, A., Walcott, B. P., Kahle, K. T., & Eskandar, E. N. (2015). Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. Journal of Clinical Neuroscience, 22(7), 1188–1190.
Khanna, A., Walcott, B. P., Kahle, K. T., & Simard, J. M. (2014). Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurgical Focus, 36(1), E11.
Glykys J, Dzhala V, Egawa K, et al. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014;345(6201):1130. doi:10.1126/science.1253146
Lee, H. K., Ahmed, M. M., King, K. C., Miranpuri, G. S., Kahle, K. T., Resnick, D. K., & Sun, D. (2014). Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. The Spine Journal : Official Journal of the North American Spine Society, 14(5), 777–81.
Walcott BP, Miller JC, Kwon CS, et al. Outcomes in severe middle cerebral artery ischemic stroke. Neurocrit Care. 2014;21(1):20-26. doi:10.1007/s12028-013-9838-x
Zhu, W., Begum, G., Pointer, K., Clark, P. A., Yang, S.-S., Lin, S.-H., … Sun, D. (2014). WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Molecular Cancer, 13(1), 31.
Kahle, K. T., Khanna, A., Clapham, D. E., & Woolf, C. J. (2014). Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain. JAMA Neurology, 71(5), 640.
de los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., … Zhang, J. (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters. Biochemical Journal, 458(3), 559–573.
Puskarjov, M., Kahle, K. T., Ruusuvuori, E., & Kaila, K. (2014). Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia, 55(6), 806–818.
Khanna, A., Kahle, K. T., Walcott, B. P., Gerzanich, V., & Simard, J. M. (2014). Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema. Translational Stroke Research, 5(1), 3–16.
Medina, I., Friedel, P., Rivera, C., Kahle, K. T., Kourdougli, N., Uvarov, P., & Pellegrino, C. (2014). Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2. Frontiers in Cellular Neuroscience, 8, 27.
Kahle, K. T., Merner, N. D., Friedel, P., Silayeva, L., Liang, B., Khanna, A., … Rouleau, G. A. (2014). Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. EMBO Reports, 15(7), 766–774.
Walcott BP, Neal JB, Sheth SA, et al. The incidence of complications in elective cranial neurosurgery associated with dural closure material. J Neurosurg. 2014;120(1):278-284. doi:10.3171/2013.8.JNS13703
Glykys J, Dzhala V, Egawa K, et al. Local impermeant anions establish the neuronal chloride concentration. Science. 2014;343(6171):670-675. doi:10.1126/science.1245423
Sun, D., & Kahle, K. T. (2014). Dysregulation of Diverse Ion Transport Pathways Controlling Cell Volume Homoestasis Contribute to Neuroglial Cell Injury Following Ischemic Stroke. Translational Stroke Research, 5(1), 1–2.
Alessi, D. R., Zhang, J., Khanna, A., Hochdorfer, T., Shang, Y., & Kahle, K. T. (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling, 7(334), re3-re3.
Khanna, A., Venteicher, A. S., Walcott, B. P., Kahle, K. T., Mordes, D. A., William, C. M., … Ogilvy, C. S. (2013). Glioblastoma Mimicking an Arteriovenous Malformation. Frontiers in Neurology, 4, 144.
Walcott, B. P., Kahle, K. T., & Simard, J. M. (2013). The DECRA Trial and Decompressive Craniectomy in Diffuse Traumatic Brain Injury: Is Decompression Really Ineffective? World Neurosurgery, 79(1), 80–81.
Khanna, A., Walcott, B. P., & Kahle, K. T. (2013). Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport. Frontiers in Neurology, 4, 78.
Khanna, A., Venteicher, A. S., Walcott, B. P., Kahle, K. T., Mordes, D. A., William, C. M., … Ogilvy, C. S. (2013). Glioblastoma Mimicking an Arteriovenous Malformation. Frontiers in Neurology, 4, 144.
Codd, P. J., Venteicher, A. S., Agarwalla, P. K., Kahle, K. T., & Jho, D. H. (2013). Endoscopic burr hole evacuation of an acute subdural hematoma. Journal of Clinical Neuroscience, 20(12), 1751–1753.
Kahle, K. T., Walcott, B. P., & Simard, J. M. (2013). Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: As good as it gets, or an iatrogenic secondary insult? Journal of Clinical Neuroscience, 20(1), 30–31.
Kahle, K. T., & Duhaime, A.-C. (2013). Intracranial-Pressure Monitoring in Traumatic Brain Injury. New England Journal of Medicine, 368(18), 1748–1752.
Ryu, J. H., Walcott, B. P., Kahle, K. T., Sheth, S. A., Peterson, R. T., Nahed, B. V., … Simard, J. M. (2013). Induced and Sustained Hypernatremia for the Prevention and Treatment of Cerebral Edema Following Brain Injury. Neurocritical Care, 19(2), 222–231.
Kahle KT, Deeb TZ, Puskarjov M, et al. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends Neurosci. 2013;36(12):726-737. doi:10.1016/j.tins.2013.08.006
Arroyo, J. P., Kahle, K. T., & Gamba, G. (2013). The SLC12 family of electroneutral cation-coupled chloride cotransporters. Molecular Aspects of Medicine, 34(2–3), 288–298.
Cleary, R. T., Sun, H., Huynh, T., Manning, S. M., Li, Y., Rotenberg, A., … Jensen, F. E. (2013). Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures. PLoS ONE, 8(3), e57148.
Walcott, B. P., Kahle, K. T., & Simard, J. M. (2012). Novel Treatment Targets for Cerebral Edema. Neurotherapeutics, 9(1), 65–72.
Walcott, B. P., Nahed, B. V., Kahle, K. T., Sekhar, L. N., & Ferreira, M. J. (2012). Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following trauma. Journal of Clinical Neuroscience, 19(1), 149–151.
Walcott, B. P., Kahle, K. T., Nahed, B. V., Coumans, J.-V. C. E., & Asaad, W. F. (2012). The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury. European Spine Journal, 21(S4), 492–494.
Algharabil, J., Kintner, D. B., Wang, Q., Begum, G., Clark, P. A., Yang, S.-S., … Sun, D. (2012). Inhibition of Na + -K + -2Cl – Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells. Cellular Physiology and Biochemistry, 30(1), 33–48.
Ben-Ari, Y., Khalilov, I., Kahle, K. T., & Cherubini, E. (2012). The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders. The Neuroscientist, 18(5), 467–486.
Stapleton, C. J., Walcott, B. P., Kahle, K. T., Codd, P. J., Nahed, B. V., Chen, L., … Jackson, E. M. (2012). Diffuse central neurocytoma with craniospinal dissemination. Journal of Clinical Neuroscience, 19(1), 163–166.
Kahle, K. T., Kahle, K. T., & Butler, W. E. (2012). Endoscopic Treatment of Hydrocephalus. Archives of Neurology, 69(5), 664.
Kahle, K. T., & Staley, K. J. (2012). Neonatal Seizures and Neuronal Transmembrane Ion Transport. Jasper’s Basic Mechanisms of the Epilepsies. Retrieved from
Walcott, B. P., Edlow, B. L., Xia, Z., Kahle, K. T., Nahed, B. V., & Schmahmann, J. D. (2012). Steroid Responsive A3243G Mutation MELAS. The Neurologist, 18(3), 159–170.
Walcott, B. P., Nahed, B. V., Sarpong, Y., Kahle, K. T., Sekhar, L. N., & Ferreira, M. J. (2012). Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques. Journal of Clinical Neuroscience, 19(1), 92–94.
Barnard, Z. R., Walcott, B. P., Kahle, K. T., Nahed, B. V., & Coumans, J. V. (2012). Hyponatremia associated with Ipilimumab-induced hypophysitis. Medical Oncology, 29(1), 374–377.
Walcott, B. P., Nahed, B. V., Kahle, K. T., Duhaime, A.-C., Sharma, N., & Eskandar, E. N. (2012). Deep brain stimulation for medically refractory life-threatening status dystonicus in children. Journal of Neurosurgery: Pediatrics, 9(1), 99–102.
Walcott, B. P., Nahed, B. V, Mohyeldin, A., Coumans, J.-V., Kahle, K. T., & Ferreira, M. J. (2012). Chordoma: current concepts, management, and future directions. The Lancet Oncology, 13(2), e69–e76.
Kessler, J. D., Kahle, K. T., Sun, T., Meerbrey, K. L., Schlabach, M. R., Schmitt, E. M., … Westbrook, T. F. (2012). A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis. Science, 335(6066), 348–353.
Simard, J. M., Sahuquillo, J., Sheth, K. N., Kahle, K. T., & Walcott, B. P. (2011). Managing Malignant Cerebral Infarction. Current Treatment Options in Neurology, 13(2), 217–229.
Aghi MK, Walcott BP, Nahed BV, et al. Determinants of initial bone graft volume loss in posterolateral lumbar fusion. J Clin Neurosci. 2011;18(9):1193-1196. doi:10.1016/j.jocn.2011.02.017
Coumans JV, Walcott BP, Butler WE, Nahed BV, Kahle KT. Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics. Neurosurg Focus. 2011;31(3):E4. doi:10.3171/2011.6.FOCUS11106
Kesari S, Advani SJ, Lawson JD, et al. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011;7(11):1335-1346. doi:10.2217/fon.11.111
Kahle, K. T., Walcott, B. P., & Staley, K. J. (2011). Resolution of Headache and Papilledema in Idiopathic Intracranial Hypertension Associated With Inhibition of Na + -K + -2Cl - Cotransport. Journal of Child Neurology, 26(2), 205–208.
Walcott BP, Kuklina EV, Nahed BV, et al. Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals. PLoS One. 2011;6(12):e29193. doi:10.1371/journal.pone.0029193
Simard JM, Kahle KT, Walcott BP. Craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011;365(4):374-376. doi:10.1056/NEJMc1106421
Schanker BD, Walcott BP, Nahed BV, Kahle KT, Li YM, Coumans JV. Familial Chiari malformation: case series. Neurosurg Focus. 2011;31(3):E1. doi:10.3171/2011.6.FOCUS11104
Walcott BP, Nahed BV, Redjal N, Stein TD, Kahle KT, Coumans JV. Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy. J Clin Neurosci. 2011;18(12):1682-1684. doi:10.1016/j.jocn.2011.03.033
Kahle KT, Walcott BP, Nahed BV, et al. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci. 2011;18(9):1245-1248. doi:10.1016/j.jocn.2011.01.014
Walcott BP, Coumans JV, Kahle KT. Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease. Neurosurg Focus. 2011;31(4):E1. doi:10.3171/2011.7.FOCUS11114
Walcott BP, Kahle KT. Blast-related traumatic brain injury in U.S. military personnel. N Engl J Med. 2011;365(9):860. doi:10.1056/NEJMc1107891
Walcott BP, Kahle KT, Wain JC, Borges LF. Giant thoracic meningocele associated with neurofibromatosis 1. Neurology. 2011;76(22):1943. doi:10.1212/WNL.0b013e31821d7667
Nahed, B. V., Ferreira, M., Babu, M. A., Terry, A. R., Walcott, B. P., Kahle, K. T., & Smith, E. R. (2011). Dural Scalp and Intracranial Hemangiomas Causing Hydrocephalus and Venous Sinus Thrombosis in an Infant. Journal of Child Neurology, 26(6), 777–781.
Pisapia JM, Walcott BP, Nahed BV, Kahle KT, Ogilvy CS. Cerebral revascularization for the treatment of complex intracranial aneurysms of the posterior circulation: microsurgical anatomy, techniques and outcomes. J Neurointerv Surg. 2011;3(3):249-254. doi:10.1136/jnis.2010.004176
Rinehart J, Vázquez N, Kahle KT, et al. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011;286(34):30171-30180. doi:10.1074/jbc.M111.222893
Walcott, B., Hanak, B., Caracci, J., Redjal, N., Nahed, B., Kahle, K., & Coumans, J.-V. E. (2011). Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample. Surgical Neurology International, 2(1), 7.
Walcott BP, Nahed BV, Kahle KT, Redjal N, Coumans JV. Determination of geographic variance in stroke prevalence using Internet search engine analytics. Neurosurg Focus. 2011;30(6):E19. doi:10.3171/2011.2.FOCUS1124
Walcott BP, Cvetanovich GL, Barnard ZR, Nahed BV, Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. J Clin Neurosci. 2011;18(10):1336-1339. doi:10.1016/j.jocn.2011.02.020
Walcott BP, Pisapia JM, Nahed BV, Kahle KT, Ogilvy CS. Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms. J Clin Neurosci. 2011;18(7):891-894. doi:10.1016/j.jocn.2011.01.002
Coumans, J.-V., Walcott, B. P., Redjal, N., Kahle, K. T., & Nahed, B. V. (2011). En bloc excision of a dermal sinus tract. Journal of Clinical Neuroscience, 18(4), 554–558.
Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet?. Epilepsia. 2011;52(9):1559-1569. doi:10.1111/j.1528-1167.2011.03203.x
Stapleton, C. J., Walcott, B. P., Linskey, K. R., Kahle, K. T., Nahed, B. V., & Asaad, W. F. (2011). Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. Journal of Clinical Neuroscience, 18(6), 857–860.
Walcott BP, Coumans JV, Mian MK, Nahed BV, Kahle KT. Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital. PLoS One. 2011;6(10):e26216. doi:10.1371/journal.pone.0026216
Bashinskaya B, Nahed BV, Redjal N, Kahle KT, Walcott BP. Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample. J Glob Infect Dis. 2011;3(4):366-370. doi:10.4103/0974-777X.91061
Hasbargen T, Ahmed MM, Miranpuri G, et al. Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. Ann N Y Acad Sci. 2010;1198:168-172. doi:10.1111/j.1749-6632.2010.05462.x
Simard JM, Kahle KT, Gerzanich V. Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4. J Neurosurg. 2010;113(3):622-629. doi:10.3171/2009.11.JNS081052
Wang Y, Suo H, Zheng Y, et al. The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture. Plant J. 2010;64(2):230-242. doi:10.1111/j.1365-313X.2010.04320.x
Eichler AF, Kahle KT, Wang DL, et al. EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol. 2010;12(11):1193-1199. doi:10.1093/neuonc/noq076
Kahle KT, Kozono D, Ng K, et al. Functional genomics to explore cancer cell vulnerabilities. Neurosurg Focus. 2010;28(1):E5. doi:10.3171/2009.10.FOCUS09212
Dzhala VI, Kuchibhotla KV, Glykys JC, et al. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010;30(35):11745-11761. doi:10.1523/JNEUROSCI.1769-10.2010
Kahle KT, Rinehart J, Lifton RP. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim Biophys Acta. 2010;1802(12):1150-1158. doi:10.1016/j.bbadis.2010.07.009
Naunheim MR, Nahed BV, Walcott BP, et al. Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature. Clin Neurol Neurosurg. 2010;112(7):575-577. doi:10.1016/j.clineuro.2010.04.001
Nahed BV, Walcott BP, Ortman AJ, et al. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010;17(8):1085-1088. doi:10.1016/j.jocn.2009.12.010
Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol. 2009;24(5):572-576. doi:10.1177/0883073809333526
Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009;24:257-265. doi:10.1152/physiol.00015.2009
Nahed BV, Ferreira M, Naunheim MR, Kahle KT, Proctor MR, Smith ER. Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. J Neurosurg Pediatr. 2009;3(4):311-315. doi:10.3171/2008.12.PEDS08206
San-Cristobal P, Pacheco-Alvarez D, Richardson C, et al. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A. 2009;106(11):4384-4389. doi:10.1073/pnas.0813238106
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