Archives

Ang, J. W. J., Khanna, A., Walcott, B. P., Kahle, K. T., & Eskandar, E. N. (2015). Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. Journal of Clinical Neuroscience, 22(7), 1188–1190. http://doi.org/10.1016/j.jocn.2015.01.018
Merner, N. D., Chandler, M. R., Bourassa, C., Liang, B., Khanna, A. R., Dion, P., … Kahle, K. T. (2015). Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience, 9, 386. http://doi.org/10.3389/fncel.2015.00386
Adragna, N. C., Ravilla, N. B., Lauf, P. K., Begum, G., Khanna, A. R., Sun, D., & Kahle, K. T. (2015). Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Frontiers in Cellular Neuroscience, 9, 255. http://doi.org/10.3389/fncel.2015.00255
Karimy, J. K., Kahle, K. T., Kurland, D. B., Yu, E., Gerzanich, V., & Simard, J. M. (2015). A novel method to study cerebrospinal fluid dynamics in rats. Journal of Neuroscience Methods, 241, 78–84. http://doi.org/10.1016/j.jneumeth.2014.12.015
Khanna, A., Simard, J. M., & Kahle, K. T. (2015). Progesterone in Traumatic Brain Injury. New England Journal of Medicine, 372(18), 1765–1767. http://doi.org/10.1056/NEJMc1503138
Friedel, P., Kahle, K. T., Zhang, J., Hertz, N., Pisella, L. I., Buhler, E., … Medina, I. (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383), ra65-ra65. http://doi.org/10.1126/scisignal.aaa0354
Begum, G., Yuan, H., Kahle, K. T., Li, L., Wang, S., Shi, Y., … Sun, D. (2015). Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke, 46(7), 1956–1965. http://doi.org/10.1161/STROKEAHA.115.008939
Kahle, K. T., Khanna, A. R., Alper, S. L., Adragna, N. C., Lauf, P. K., Sun, D., & Delpire, E. (2015). K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in Molecular Medicine, 21(8), 513–523. http://doi.org/10.1016/j.molmed.2015.05.008
Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015). GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia, 63(1), 23–36. http://doi.org/10.1002/glia.22730
Alessi, D. R., Zhang, J., Khanna, A., Hochdorfer, T., Shang, Y., & Kahle, K. T. (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling, 7(334), re3-re3. http://doi.org/10.1126/scisignal.2005365
Sun, D., & Kahle, K. T. (2014). Dysregulation of Diverse Ion Transport Pathways Controlling Cell Volume Homoestasis Contribute to Neuroglial Cell Injury Following Ischemic Stroke. Translational Stroke Research, 5(1), 1–2. http://doi.org/10.1007/s12975-014-0324-3
Kahle, K. T., Merner, N. D., Friedel, P., Silayeva, L., Liang, B., Khanna, A., … Rouleau, G. A. (2014). Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. EMBO Reports, 15(7), 766–774. http://doi.org/10.15252/embr.201438840
Medina, I., Friedel, P., Rivera, C., Kahle, K. T., Kourdougli, N., Uvarov, P., & Pellegrino, C. (2014). Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2. Frontiers in Cellular Neuroscience, 8, 27. http://doi.org/10.3389/fncel.2014.00027
Khanna, A., Kahle, K. T., Walcott, B. P., Gerzanich, V., & Simard, J. M. (2014). Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema. Translational Stroke Research, 5(1), 3–16. http://doi.org/10.1007/s12975-013-0307-9
Puskarjov, M., Kahle, K. T., Ruusuvuori, E., & Kaila, K. (2014). Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia, 55(6), 806–818. http://doi.org/10.1111/epi.12620
de los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., … Zhang, J. (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters. Biochemical Journal, 458(3), 559–573. http://doi.org/10.1042/BJ20131478
Kahle, K. T., Khanna, A., Clapham, D. E., & Woolf, C. J. (2014). Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain. JAMA Neurology, 71(5), 640. http://doi.org/10.1001/jamaneurol.2014.21
Zhu, W., Begum, G., Pointer, K., Clark, P. A., Yang, S.-S., Lin, S.-H., … Sun, D. (2014). WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Molecular Cancer, 13(1), 31. http://doi.org/10.1186/1476-4598-13-31
Lee, H. K., Ahmed, M. M., King, K. C., Miranpuri, G. S., Kahle, K. T., Resnick, D. K., & Sun, D. (2014). Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. The Spine Journal : Official Journal of the North American Spine Society, 14(5), 777–81. http://doi.org/10.1016/j.spinee.2013.06.100
Khanna, A., Walcott, B. P., Kahle, K. T., & Simard, J. M. (2014). Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurgical Focus, 36(1), E11. http://doi.org/10.3171/2013.10.FOCUS13404
Glykys J, Dzhala V, Egawa K, et al. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014;345(6201):1130. doi:10.1126/science.1253146
Walcott BP, Miller JC, Kwon CS, et al. Outcomes in severe middle cerebral artery ischemic stroke. Neurocrit Care. 2014;21(1):20-26. doi:10.1007/s12028-013-9838-x
Walcott BP, Neal JB, Sheth SA, et al. The incidence of complications in elective cranial neurosurgery associated with dural closure material. J Neurosurg. 2014;120(1):278-284. doi:10.3171/2013.8.JNS13703
Glykys J, Dzhala V, Egawa K, et al. Local impermeant anions establish the neuronal chloride concentration. Science. 2014;343(6171):670-675. doi:10.1126/science.1245423
Cleary, R. T., Sun, H., Huynh, T., Manning, S. M., Li, Y., Rotenberg, A., … Jensen, F. E. (2013). Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures. PLoS ONE, 8(3), e57148. http://doi.org/10.1371/journal.pone.0057148
Arroyo, J. P., Kahle, K. T., & Gamba, G. (2013). The SLC12 family of electroneutral cation-coupled chloride cotransporters. Molecular Aspects of Medicine, 34(2–3), 288–298. http://doi.org/10.1016/j.mam.2012.05.002
Ryu, J. H., Walcott, B. P., Kahle, K. T., Sheth, S. A., Peterson, R. T., Nahed, B. V., … Simard, J. M. (2013). Induced and Sustained Hypernatremia for the Prevention and Treatment of Cerebral Edema Following Brain Injury. Neurocritical Care, 19(2), 222–231. http://doi.org/10.1007/s12028-013-9824-3
Kahle, K. T., & Duhaime, A.-C. (2013). Intracranial-Pressure Monitoring in Traumatic Brain Injury. New England Journal of Medicine, 368(18), 1748–1752. http://doi.org/10.1056/NEJMc1301076
Kahle, K. T., Walcott, B. P., & Simard, J. M. (2013). Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: As good as it gets, or an iatrogenic secondary insult? Journal of Clinical Neuroscience, 20(1), 30–31. http://doi.org/10.1016/j.jocn.2012.10.004
Codd, P. J., Venteicher, A. S., Agarwalla, P. K., Kahle, K. T., & Jho, D. H. (2013). Endoscopic burr hole evacuation of an acute subdural hematoma. Journal of Clinical Neuroscience, 20(12), 1751–1753. http://doi.org/10.1016/j.jocn.2013.02.019
Khanna, A., Venteicher, A. S., Walcott, B. P., Kahle, K. T., Mordes, D. A., William, C. M., … Ogilvy, C. S. (2013). Glioblastoma Mimicking an Arteriovenous Malformation. Frontiers in Neurology, 4, 144. http://doi.org/10.3389/fneur.2013.00144
Khanna, A., Walcott, B. P., & Kahle, K. T. (2013). Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport. Frontiers in Neurology, 4, 78. http://doi.org/10.3389/fneur.2013.00078
Walcott, B. P., Kahle, K. T., & Simard, J. M. (2013). The DECRA Trial and Decompressive Craniectomy in Diffuse Traumatic Brain Injury: Is Decompression Really Ineffective? World Neurosurgery, 79(1), 80–81. http://doi.org/10.1016/j.wneu.2012.11.014
Khanna, A., Venteicher, A. S., Walcott, B. P., Kahle, K. T., Mordes, D. A., William, C. M., … Ogilvy, C. S. (2013). Glioblastoma Mimicking an Arteriovenous Malformation. Frontiers in Neurology, 4, 144. http://doi.org/10.3389/fneur.2013.00144
Kahle KT, Deeb TZ, Puskarjov M, et al. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends Neurosci. 2013;36(12):726-737. doi:10.1016/j.tins.2013.08.006
Kessler, J. D., Kahle, K. T., Sun, T., Meerbrey, K. L., Schlabach, M. R., Schmitt, E. M., … Westbrook, T. F. (2012). A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis. Science, 335(6066), 348–353. http://doi.org/10.1126/science.1212728
Walcott, B. P., Nahed, B. V, Mohyeldin, A., Coumans, J.-V., Kahle, K. T., & Ferreira, M. J. (2012). Chordoma: current concepts, management, and future directions. The Lancet Oncology, 13(2), e69–e76. http://doi.org/10.1016/S1470-2045(11)70337-0
Walcott, B. P., Nahed, B. V., Kahle, K. T., Duhaime, A.-C., Sharma, N., & Eskandar, E. N. (2012). Deep brain stimulation for medically refractory life-threatening status dystonicus in children. Journal of Neurosurgery: Pediatrics, 9(1), 99–102. http://doi.org/10.3171/2011.10.PEDS11360
Barnard, Z. R., Walcott, B. P., Kahle, K. T., Nahed, B. V., & Coumans, J. V. (2012). Hyponatremia associated with Ipilimumab-induced hypophysitis. Medical Oncology, 29(1), 374–377. http://doi.org/10.1007/s12032-010-9794-7
Walcott, B. P., Nahed, B. V., Sarpong, Y., Kahle, K. T., Sekhar, L. N., & Ferreira, M. J. (2012). Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques. Journal of Clinical Neuroscience, 19(1), 92–94. http://doi.org/10.1016/j.jocn.2011.08.001
Walcott, B. P., Edlow, B. L., Xia, Z., Kahle, K. T., Nahed, B. V., & Schmahmann, J. D. (2012). Steroid Responsive A3243G Mutation MELAS. The Neurologist, 18(3), 159–170. http://doi.org/10.1097/NRL.0b013e318247bcd8
Kahle, K. T., & Staley, K. J. (2012). Neonatal Seizures and Neuronal Transmembrane Ion Transport. Jasper’s Basic Mechanisms of the Epilepsies. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22787602
Kahle, K. T., Kahle, K. T., & Butler, W. E. (2012). Endoscopic Treatment of Hydrocephalus. Archives of Neurology, 69(5), 664. http://doi.org/10.1001/archneurol.2011.1766
Stapleton, C. J., Walcott, B. P., Kahle, K. T., Codd, P. J., Nahed, B. V., Chen, L., … Jackson, E. M. (2012). Diffuse central neurocytoma with craniospinal dissemination. Journal of Clinical Neuroscience, 19(1), 163–166. http://doi.org/10.1016/j.jocn.2011.07.016
Ben-Ari, Y., Khalilov, I., Kahle, K. T., & Cherubini, E. (2012). The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders. The Neuroscientist, 18(5), 467–486. http://doi.org/10.1177/1073858412438697
Algharabil, J., Kintner, D. B., Wang, Q., Begum, G., Clark, P. A., Yang, S.-S., … Sun, D. (2012). Inhibition of Na + -K + -2Cl – Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells. Cellular Physiology and Biochemistry, 30(1), 33–48. http://doi.org/10.1159/000339047
Walcott, B. P., Kahle, K. T., Nahed, B. V., Coumans, J.-V. C. E., & Asaad, W. F. (2012). The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury. European Spine Journal, 21(S4), 492–494. http://doi.org/10.1007/s00586-011-2116-8
Walcott, B. P., Nahed, B. V., Kahle, K. T., Sekhar, L. N., & Ferreira, M. J. (2012). Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following trauma. Journal of Clinical Neuroscience, 19(1), 149–151. http://doi.org/10.1016/j.jocn.2011.05.017
Walcott, B. P., Kahle, K. T., & Simard, J. M. (2012). Novel Treatment Targets for Cerebral Edema. Neurotherapeutics, 9(1), 65–72. http://doi.org/10.1007/s13311-011-0087-4
Stapleton, C. J., Walcott, B. P., Linskey, K. R., Kahle, K. T., Nahed, B. V., & Asaad, W. F. (2011). Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. Journal of Clinical Neuroscience, 18(6), 857–860. http://doi.org/10.1016/j.jocn.2010.11.004
Coumans, J.-V., Walcott, B. P., Redjal, N., Kahle, K. T., & Nahed, B. V. (2011). En bloc excision of a dermal sinus tract. Journal of Clinical Neuroscience, 18(4), 554–558. http://doi.org/10.1016/j.jocn.2010.11.008
Walcott, B., Hanak, B., Caracci, J., Redjal, N., Nahed, B., Kahle, K., & Coumans, J.-V. E. (2011). Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample. Surgical Neurology International, 2(1), 7. http://doi.org/10.4103/2152-7806.76144
Nahed, B. V., Ferreira, M., Babu, M. A., Terry, A. R., Walcott, B. P., Kahle, K. T., & Smith, E. R. (2011). Dural Scalp and Intracranial Hemangiomas Causing Hydrocephalus and Venous Sinus Thrombosis in an Infant. Journal of Child Neurology, 26(6), 777–781. http://doi.org/10.1177/0883073810390694
Kahle, K. T., Walcott, B. P., & Staley, K. J. (2011). Resolution of Headache and Papilledema in Idiopathic Intracranial Hypertension Associated With Inhibition of Na + -K + -2Cl - Cotransport. Journal of Child Neurology, 26(2), 205–208. http://doi.org/10.1177/0883073810391264
Simard, J. M., Sahuquillo, J., Sheth, K. N., Kahle, K. T., & Walcott, B. P. (2011). Managing Malignant Cerebral Infarction. Current Treatment Options in Neurology, 13(2), 217–229. http://doi.org/10.1007/s11940-010-0110-9
Bashinskaya B, Nahed BV, Redjal N, Kahle KT, Walcott BP. Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample. J Glob Infect Dis. 2011;3(4):366-370. doi:10.4103/0974-777X.91061
Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet?. Epilepsia. 2011;52(9):1559-1569. doi:10.1111/j.1528-1167.2011.03203.x
Walcott BP, Kahle KT, Wain JC, Borges LF. Giant thoracic meningocele associated with neurofibromatosis 1. Neurology. 2011;76(22):1943. doi:10.1212/WNL.0b013e31821d7667
Walcott BP, Nahed BV, Kahle KT, Redjal N, Coumans JV. Determination of geographic variance in stroke prevalence using Internet search engine analytics. Neurosurg Focus. 2011;30(6):E19. doi:10.3171/2011.2.FOCUS1124
Walcott BP, Cvetanovich GL, Barnard ZR, Nahed BV, Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. J Clin Neurosci. 2011;18(10):1336-1339. doi:10.1016/j.jocn.2011.02.020
Pisapia JM, Walcott BP, Nahed BV, Kahle KT, Ogilvy CS. Cerebral revascularization for the treatment of complex intracranial aneurysms of the posterior circulation: microsurgical anatomy, techniques and outcomes. J Neurointerv Surg. 2011;3(3):249-254. doi:10.1136/jnis.2010.004176
Walcott BP, Kahle KT. Blast-related traumatic brain injury in U.S. military personnel. N Engl J Med. 2011;365(9):860. doi:10.1056/NEJMc1107891
Coumans JV, Walcott BP, Butler WE, Nahed BV, Kahle KT. Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics. Neurosurg Focus. 2011;31(3):E4. doi:10.3171/2011.6.FOCUS11106
Simard JM, Kahle KT, Walcott BP. Craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011;365(4):374-376. doi:10.1056/NEJMc1106421
Walcott BP, Coumans JV, Mian MK, Nahed BV, Kahle KT. Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital. PLoS One. 2011;6(10):e26216. doi:10.1371/journal.pone.0026216
Kesari S, Advani SJ, Lawson JD, et al. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011;7(11):1335-1346. doi:10.2217/fon.11.111
Schanker BD, Walcott BP, Nahed BV, Kahle KT, Li YM, Coumans JV. Familial Chiari malformation: case series. Neurosurg Focus. 2011;31(3):E1. doi:10.3171/2011.6.FOCUS11104
Walcott BP, Pisapia JM, Nahed BV, Kahle KT, Ogilvy CS. Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms. J Clin Neurosci. 2011;18(7):891-894. doi:10.1016/j.jocn.2011.01.002
Walcott BP, Coumans JV, Kahle KT. Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease. Neurosurg Focus. 2011;31(4):E1. doi:10.3171/2011.7.FOCUS11114
Walcott BP, Kuklina EV, Nahed BV, et al. Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals. PLoS One. 2011;6(12):e29193. doi:10.1371/journal.pone.0029193
Walcott BP, Nahed BV, Redjal N, Stein TD, Kahle KT, Coumans JV. Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy. J Clin Neurosci. 2011;18(12):1682-1684. doi:10.1016/j.jocn.2011.03.033
Rinehart J, Vázquez N, Kahle KT, et al. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011;286(34):30171-30180. doi:10.1074/jbc.M111.222893
Kahle KT, Walcott BP, Nahed BV, et al. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci. 2011;18(9):1245-1248. doi:10.1016/j.jocn.2011.01.014
Aghi MK, Walcott BP, Nahed BV, et al. Determinants of initial bone graft volume loss in posterolateral lumbar fusion. J Clin Neurosci. 2011;18(9):1193-1196. doi:10.1016/j.jocn.2011.02.017
Kahle KT, Kozono D, Ng K, et al. Functional genomics to explore cancer cell vulnerabilities. Neurosurg Focus. 2010;28(1):E5. doi:10.3171/2009.10.FOCUS09212
Eichler AF, Kahle KT, Wang DL, et al. EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol. 2010;12(11):1193-1199. doi:10.1093/neuonc/noq076
Nahed BV, Walcott BP, Ortman AJ, et al. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010;17(8):1085-1088. doi:10.1016/j.jocn.2009.12.010
Kahle KT, Rinehart J, Lifton RP. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim Biophys Acta. 2010;1802(12):1150-1158. doi:10.1016/j.bbadis.2010.07.009
Simard JM, Kahle KT, Gerzanich V. Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4. J Neurosurg. 2010;113(3):622-629. doi:10.3171/2009.11.JNS081052
Naunheim MR, Nahed BV, Walcott BP, et al. Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature. Clin Neurol Neurosurg. 2010;112(7):575-577. doi:10.1016/j.clineuro.2010.04.001
Wang Y, Suo H, Zheng Y, et al. The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture. Plant J. 2010;64(2):230-242. doi:10.1111/j.1365-313X.2010.04320.x
Hasbargen T, Ahmed MM, Miranpuri G, et al. Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. Ann N Y Acad Sci. 2010;1198:168-172. doi:10.1111/j.1749-6632.2010.05462.x
Dzhala VI, Kuchibhotla KV, Glykys JC, et al. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010;30(35):11745-11761. doi:10.1523/JNEUROSCI.1769-10.2010
Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009;24:257-265. doi:10.1152/physiol.00015.2009
Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol. 2009;24(5):572-576. doi:10.1177/0883073809333526
San-Cristobal P, Pacheco-Alvarez D, Richardson C, et al. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A. 2009;106(11):4384-4389. doi:10.1073/pnas.0813238106
Nahed BV, Ferreira M, Naunheim MR, Kahle KT, Proctor MR, Smith ER. Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. J Neurosurg Pediatr. 2009;3(4):311-315. doi:10.3171/2008.12.PEDS08206