Archives

Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015). GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia, 63(1), 23–36. http://doi.org/10.1002/glia.22730

Kahle, K. T., Khanna, A. R., Alper, S. L., Adragna, N. C., Lauf, P. K., Sun, D., & Delpire, E. (2015). K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in Molecular Medicine, 21(8), 513–523. http://doi.org/10.1016/j.molmed.2015.05.008

Begum, G., Yuan, H., Kahle, K. T., Li, L., Wang, S., Shi, Y., … Sun, D. (2015). Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke, 46(7), 1956–1965. http://doi.org/10.1161/STROKEAHA.115.008939

Friedel, P., Kahle, K. T., Zhang, J., Hertz, N., Pisella, L. I., Buhler, E., … Medina, I. (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383), ra65-ra65. http://doi.org/10.1126/scisignal.aaa0354

Khanna, A., Simard, J. M., & Kahle, K. T. (2015). Progesterone in Traumatic Brain Injury. New England Journal of Medicine, 372(18), 1765–1767. http://doi.org/10.1056/NEJMc1503138

Karimy, J. K., Kahle, K. T., Kurland, D. B., Yu, E., Gerzanich, V., & Simard, J. M. (2015). A novel method to study cerebrospinal fluid dynamics in rats. Journal of Neuroscience Methods, 241, 78–84. http://doi.org/10.1016/j.jneumeth.2014.12.015

Adragna, N. C., Ravilla, N. B., Lauf, P. K., Begum, G., Khanna, A. R., Sun, D., & Kahle, K. T. (2015). Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Frontiers in Cellular Neuroscience, 9, 255. http://doi.org/10.3389/fncel.2015.00255

Merner, N. D., Chandler, M. R., Bourassa, C., Liang, B., Khanna, A. R., Dion, P., … Kahle, K. T. (2015). Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience, 9, 386. http://doi.org/10.3389/fncel.2015.00386

Ang, J. W. J., Khanna, A., Walcott, B. P., Kahle, K. T., & Eskandar, E. N. (2015). Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. Journal of Clinical Neuroscience, 22(7), 1188–1190. http://doi.org/10.1016/j.jocn.2015.01.018

Khanna, A., Walcott, B. P., Kahle, K. T., & Simard, J. M. (2014). Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurgical Focus, 36(1), E11. http://doi.org/10.3171/2013.10.FOCUS13404

Glykys J, Dzhala V, Egawa K, et al. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014;345(6201):1130. doi:10.1126/science.1253146

Lee, H. K., Ahmed, M. M., King, K. C., Miranpuri, G. S., Kahle, K. T., Resnick, D. K., & Sun, D. (2014). Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. The Spine Journal : Official Journal of the North American Spine Society, 14(5), 777–81. http://doi.org/10.1016/j.spinee.2013.06.100

Walcott BP, Miller JC, Kwon CS, et al. Outcomes in severe middle cerebral artery ischemic stroke. Neurocrit Care. 2014;21(1):20-26. doi:10.1007/s12028-013-9838-x

Zhu, W., Begum, G., Pointer, K., Clark, P. A., Yang, S.-S., Lin, S.-H., … Sun, D. (2014). WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Molecular Cancer, 13(1), 31. http://doi.org/10.1186/1476-4598-13-31

Kahle, K. T., Khanna, A., Clapham, D. E., & Woolf, C. J. (2014). Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain. JAMA Neurology, 71(5), 640. http://doi.org/10.1001/jamaneurol.2014.21

de los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., … Zhang, J. (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters. Biochemical Journal, 458(3), 559–573. http://doi.org/10.1042/BJ20131478

Puskarjov, M., Kahle, K. T., Ruusuvuori, E., & Kaila, K. (2014). Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia, 55(6), 806–818. http://doi.org/10.1111/epi.12620

Khanna, A., Kahle, K. T., Walcott, B. P., Gerzanich, V., & Simard, J. M. (2014). Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema. Translational Stroke Research, 5(1), 3–16. http://doi.org/10.1007/s12975-013-0307-9

Medina, I., Friedel, P., Rivera, C., Kahle, K. T., Kourdougli, N., Uvarov, P., & Pellegrino, C. (2014). Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2. Frontiers in Cellular Neuroscience, 8, 27. http://doi.org/10.3389/fncel.2014.00027

Kahle, K. T., Merner, N. D., Friedel, P., Silayeva, L., Liang, B., Khanna, A., … Rouleau, G. A. (2014). Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. EMBO Reports, 15(7), 766–774. http://doi.org/10.15252/embr.201438840