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Vein of Galen Malformations

Vein of Galen Malformations (VOGMs) are a rare type of developmental brain arteriovenous malformation (AVM). Interestingly, true VOGMs are, in fact, abnormal connections to the median prosencephalic vein. This median prosencephalic vein is the embryonic precursor of the mature Vein of Galen, and thus a true VOGM does not affect the Vein of Galen proper. Although this is a semantic misconception that persists in modern medical literature today, the pathogenic mechanisms of VOGM are also ill-conceived. This disease can be lethal if untreated and often leads to developmental delays with other neurologic abnormalities.

The Kahle laboratory's VOGM study aims to understand the pathogenesis of VOGMs through genetic sequencing and alliances with highly experienced centers and physicians across the world. We lead the International Consortium for Vein of Galen Genomics, which to date has sequenced the DNA of over 50 VOGM patients and their parents.

Affected individuals and their families are welcomed and encouraged to join!