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2020 Highlights

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November 2020

Volume 26, Issue 11

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with neurosurgical CSF diversion with high morbidity and failure rates. The poor neurodevelopmental outcomes and persistence of ventriculomegaly in some post-surgical patients...


May 2020

Volume 16, Issue 5

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

Hydrocephalus is the most common neurosurgical disorder worldwide and is characterized by enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles resulting from failed CSF homeostasis. Since the 1840s, physicians have observed inflammation in the brain and the CSF spaces in both posthaemorrhagic hydrocephalus (PHH)...


January 07, 2020

Volume 11, Issue 1

Modulation of brain cation-Cl - cotransport via the SPAK kinase inhibitor ZT-1a

The SLC12A cation-Cl− cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx and inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs. Upregulation of SPAK-dependent CCC phosphorylation has been implicated in several neurological diseases. Using a scaffold-hybrid strategy...


Date P, Ackermann P, Furey C, et al. Author Correction: Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus. Sci Rep. 2020;10(1):2791. Published 2020 Feb 12. doi:10.1038/s41598-020-59301-y
Dur AH, Tang T, Viviano S, et al. In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces. Fluids Barriers CNS. 2020;17(1):72. Published 2020 Dec 11. doi:10.1186/s12987-020-00234-z
Hong CS, Vasquez JC, Kundishora AJ, et al. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. NPJ Genom Med. 2020;5:23. Published 2020 Jun 1. doi:10.1038/s41525-020-0130-7
Elsamadicy AA, Koo AB, Lee M, et al. Risk Factors Portending Extended Length of Stay After Suboccipital Decompression for Adult Chiari I Malformation. World Neurosurg. 2020;138:e515-e522. doi:10.1016/j.wneu.2020.02.158
Elsamadicy AA, Koo AB, David WB, et al. Comparison of epidemiology, treatments, and outcomes in pediatric versus adult ependymoma. Neurooncol Adv. 2020;2(1):vdaa019. Published 2020 Feb 21. doi:10.1093/noajnl/vdaa019
Elsamadicy AA, Koo AB, Lee V, et al. Risk Factors for the Development of Post-Traumatic Hydrocephalus in Children. World Neurosurg. 2020;141:e105-e111. doi:10.1016/j.wneu.2020.04.216
Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT. New drugs on the horizon for cerebral edema: what's in the clinical development pipeline?. Expert Opin Investig Drugs. 2020;29(10):1099-1105. doi:10.1080/13543784.2020.1813715
Duy PQ, He M, He Z, Kahle KT. Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability. Expert Opin Ther Targets. 2020;24(7):629-637. doi:10.1080/14728222.2020.1762174
Karimy JK, Reeves BC, Kahle KT. Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury. Expert Opin Ther Targets. 2020;24(6):525-533. doi:10.1080/14728222.2020.1752182
Jin SC, Dong W, Kundishora AJ, et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nat Med. 2020;26(11):1754-1765. doi:10.1038/s41591-020-1090-2
Karimy JK, Reeves BC, Damisah E, et al. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nat Rev Neurol. 2020;16(5):285-296. doi:10.1038/s41582-020-0321-y
Zhang J, Bhuiyan MIH, Zhang T, et al. Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Nat Commun. 2020;11(1):78. Published 2020 Jan 7. doi:10.1038/s41467-019-13851-6
Dong W, Jin SC, Allocco A, et al. Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia. iScience. 2020;23(10):101552. Published 2020 Sep 11. doi:10.1016/j.isci.2020.101552
Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, Alper SL, Lundgaard I, Nedergaard M, and Kahle KT. Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus. Trends Mol Med. 2020 Mar;26(3):285-295. PMID: 31959516.
Koo AB, Elsamadicy AA, Kundishora AJ, et al. Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis [published online ahead of print, 2020 Jan 7]. World Neurosurg. 2020;S1878-8750(19)33207-3. doi:10.1016/j.wneu.2019.12.175
Kundishora AJ, Reeves BC, Nelson-Williams C, et al. Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm [published online ahead of print, 2020 Jan 11]. Clin Genet. 2020;10.1111/cge.13703. doi:10.1111/cge.13703
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