Principal Investigator

Kristopher T. Kahle, M.D., Ph.D.

Pediatric Neurosurgeon | Neurosurgeon | Geneticist

- Director, Pediatric Neurosurgery, Massachusetts General Hospital

- Director, Harvard Center for Hydrocephalus and Neurodevelopmental Disorders (HAND)- Member, Yale-NIH Centers for Mendelian Genomics

Dr. Kahle is the Director of Pediatric Neurosurgery at the Massachusetts General Hospital (MGH) and the Harvard Center for Hydrocephalus and Neurodevelopmental Disorders (HAND). He is a board-certified pediatric neurosurgeon, with experience in a broad range of pediatric neurosurgical disorders including brain and spinal cord tumors and cysts, all types of hydrocephalus, Chiari malformation, spina bifida, vascular malformations, and others. He also treats these conditions in transitional age patients and adults, providing continuity of care across the age spectrum. He is highly skilled in both open and endoscopic/minimally invasive neurosurgical techniques.


Dr. Kahle is a fellow of the American Association of Neurological Surgeons (AANS) and a member of numerous medical organizations, including the AANS, Congress of Neurological Surgeons (CNS), American Society of Pediatric Neurosurgeons (ASPN), and the International Society of Pediatric Neurosurgeons (ISPN).


Dr. Kahle graduated cum laude from the University of Chicago in 1999 with degrees in Biology and Philosophy. He received his M.D. from Yale School of Medicine in 2007, where he also received his Ph.D. working in the laboratory of human geneticist Richard Lifton. He completed his neurosurgery residency training at MGH in 2014, as well as a post-doctoral research fellowship at Harvard University with co-mentors Stephen Elledge and David Clapham. He completed a clinical pediatric neurosurgery fellowship at Boston Children’s Hospital, where he was Shellito staff associate and Instructor of Neurosurgery at Harvard Medical School. Dr. Kahle returned to New Haven to join the Yale School of Medicine faculty, where he was Assistant Professor of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, and Director of Neonatal and Congenital Anomaly Neurosurgery from 2016-2021.

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Garrett Allington

  PhD Candidate

  Yale University 

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Tyrone Despenza Jr.

MD/PhD Candidate

Yale School of Medicine

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Weilai Dong

PhD Candidate

 Yale University

Graduate Student

Rockefeller University


Jason Karimy

MD Candidate

Quinnipac School of Medicine


Adam Kundishora, MD

Chief Neurosurgery Resident

Yale New Haven Hospital


Arnaud Marlier, PhD

Senior Research Scientist

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Kedous Mekbib

MD/MHS Candidate

Yale School of Medicine


Andres Moreno De Luca, MD

Associate Neuroradiologist, Department of Radiology
Assistant Professor, Autism & Developmental Medicine Institute and Genomic Medicine Institute


Carol Nelson-Williams

Senior Research Scientist

Yale University


Jack Ocken 

Yale College

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Stephanie Robert, MD, PhD

Resident Physician, Department of Neurosurgery

Postdoctoral Fellow, Kahle Lab

Yale New Haven Hospital

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Duy Phan

MD/PhD Candidate

Yale School of Medicine


Amar Sheth

MD Candidate

Yale School of Medicine

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Benjamin Reeves

MD Candidate

Yale School of Medicine

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Amrita Singh

MD Candidate

Yale School of Medicine

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Hannah Smith, BS
Clinical Research Coordinator, Kahle Lab

Massachusetts General Hospital


Junhui Zhang

Senior Research Scientist

Yale University


Shujuan Zhao

PhD Candidate

Washington University

Lab Alumni

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August Allocco

Clinical Technologist

Yale University

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Ashley Dunbar

MD Student

Quinnipiac School of Medicine

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Jonathan Gaillard, MD

HHMI Medical Research Fellow

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Will Sullivan

Yale College


Sierra Conine

Postgraduate Associate in Neurosurgery

Yale University

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Daniel Duran, MD

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Ava Hunt

MD Student

Rutgers School of Medicine

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Xue Zeng

PhD Candidate, Yale University

Graduate Assistant, Rockefeller University

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Eyiyemisi Damisah, MD

Assistant Professor of Neurosurgery

Yale University

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Charuta Furey, MD


Shreyas Panchagnula, MD, MHS

Resident, University of Maryland Medical Center Neurosurgery Department